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2006\u5e74\u9996\u53d1\u7684\u662f4\u4ef7\u5bab\u9888\u764c\u75ab\u82d7\uff0c\u5373\u80fd\u9884\u9632HPV-6\u300111\u300116\u300118\u56db\u79cdHPV\uff0c\u6db5\u76d670%\u7684\u5bab\u9888\u764c\u30022017\u5e74\uff0c9\u4ef7\u75ab\u82d7Gardasil 9\u95ee\u4e16\uff0c\u8fd9\u4e00\u6539\u8fdb\u578b\u7684\u75ab\u82d7\u5728\u539f4\u4ef7\u75ab\u82d7\u7684\u57fa\u7840\u4e0a\uff0c\u53c8\u52a0\u8fdb\u4e86HPV-31\u300133\u300145\u300152\u300158\u3002\u7406\u8bba\u4e0a\uff0cGardasil 9\u7684\u6db5\u76d6\u8303\u56f4\u5c06\u9ad8\u4e8e70%\u7684\u5bab\u9888\u764c\u3002<\/p>\n

\u7814\u5236HPV\u75ab\u82d7\u7684\u521d\u8877\u662f\u4e3a\u4e86\u9884\u9632\u5bab\u9888\u764c\u3002\u7136\u800c\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u663e\u793aHPV\u8fd8\u53ef\u80fd\u4e0e\u5176\u5b83\u764c\u75c7\u6709\u5173\uff0c\u90a3\u4e48\u5bab\u9888\u764c\u75ab\u82d7\u5728\u4fdd\u62a4\u5176\u5b83\u7ec4\u7ec7\u5668\u5b98\u514d\u53d7HPV\u611f\u67d3\u65b9\u9762\u662f\u5426\u6709\u6548\uff1f\u76f8\u5173\u7814\u7a76\u8868\u660e\uff0cHPV\u53ef\u80fd\u4e0e\u809b\u95e8\u764c\u7684\u53d1\u751f\u5bc6\u5207\u76f8\u5173\uff0c\u800c\u5bab\u9888\u764c\u75ab\u82d7\u7684\u63a5\u79cd\u5728\u9632\u6b62HPV\u809b\u95e8\u611f\u67d3\u65b9\u9762\u7684\u6709\u6548\u6027\u9ad8\u8fbe84%\u2463\u3002\u53e6\u5916\uff0c\u7f8e\u56fd\u8fd170%\u7684\u53e3\u54bd\u764c(oropharyngeal cancers)\u5448HPV\u9633\u6027\uff0c\u800c\u4e14\u4e3b\u8981\u662fHPV-16\u9633\u6027\u2464\uff0c\u8fd9\u4e00HPV\u4e9a\u578b\u7684\u611f\u67d3\u9884\u9632\u5df2\u7ecf\u5305\u542b\u5728\u4e86\u6700\u521d\u76844\u4ef7\u75ab\u82d7\u5185\u4e86\u3002\u968f\u7740\u7814\u7a76\u7684\u4e0d\u65ad\u6df1\u5165\uff0c\u5bab\u9888\u764c\u75ab\u82d7\u7684\u4f5c\u7528\u8303\u56f4\u5c06\u4e0d\u4ec5\u4ec5\u5c40\u9650\u4e8e\u5bab\u9888\u764c\u3002<\/p>\n

\u65e0\u8bba\u662f\u809b\u95e8\u764c\uff0c\u8fd8\u662f\u53e3\u54bd\u764c\uff0c\u90fd\u4e0d\u662f\u5973\u6027\u7684\u4e13\u5229\u3002\u4e5f\u8bb8\u662f\u51fa\u4e8e\u8fd9\u4e00\u8003\u8651\uff0c\u73b0\u5728\u5bab\u9888\u764c\u75ab\u82d7\u7684\u63a5\u79cd\u6709\u671b\u6269\u5927\u5230\u7537\u6027\u7fa4\u4f53\u3002\u53e6\u5916\uff0c\u5df2\u6709\u4e13\u95e8\u7684\u7814\u7a76\u8bc1\u5b9e\uff0c\u5bab\u9888\u764c\u75ab\u82d7\u5728\u4e24\u6027\u4e4b\u95f4\u6709\u5f88\u5f3a\u7684\u4ea4\u53c9\u9632\u8303\u529f\u80fd\u3002\u6bd4\u5982\uff0c\u5728\u5973\u6027\u4e2d\u63a5\u79cd\u5bab\u9888\u764c\u75ab\u82d7\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u5973\u6027\u611f\u67d3HPV\u7684\u4eba\u6570\uff0c\u5207\u65ad\u4e86\u5f88\u591a\u6f5c\u5728\u7684\u4f20\u67d3\u9014\u5f84\uff0c\u4ece\u800c\u5927\u5927\u964d\u4f4e\u4e86\u6ca1\u6709\u63a5\u79cd\u75ab\u82d7\u7684\u7537\u6027\u611f\u67d3HPV\u7684\u98ce\u9669\u3002<\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u95ee\u4e1612\u5e74\u6765\uff0c\u5bab\u9888\u764c\u75ab\u82d7\u5728\u9884\u9632HPV\u611f\u67d3\u548c\u524d\u671f\u5bab\u9888\u764c(precancerous)\u53d1\u751f\u65b9\u9762\u5df2\u663e\u793a\u4e86\u5de8\u5927\u7684\u5a01\u529b\u3002\u622a\u81f32014\u5e74\uff0c\u5bab\u9888\u764c\u75ab\u82d7\u5df2\u7ecf\u88ab\u63a8\u5e7f\u5230\u5168\u4e16\u754c120\u591a\u4e2a\u56fd\u5bb6\uff0c\u6570\u4ee5\u4ebf\u8ba1\u7684\u5973\u6027\u53d7\u5230\u4e86\u75ab\u82d7\u7684\u4fdd\u62a4\u3002\u7279\u522b\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u57282016\u5e74\uff0c\u5bab\u9888\u764c\u75ab\u82d7\u83b7\u6279\u8fdb\u5165\u5468\u5065\u535a\u58eb\u7684\u7956\u56fd\uff1bGardasil 4\u548c\u6700\u65b0\u7684Gardasil 9\u4e5f\u5206\u522b\u4e8e2017\u5e74\u548c2018\u5e74\u83b7\u5f97\u4e2d\u56fd\u5927\u9646\u7684\u51c6\u5165\u8bc1\uff0c\u4eba\u4eec\u518d\u4e5f\u4e0d\u7528\u4e3a\u63a5\u79cd\u75ab\u82d7\u800c\u5343\u91cc\u8fe2\u8fe2\u8fdc\u8d74\u9999\u6e2f\u3001\u6fb3\u95e8\u3002<\/p>\n

\u4e9a\u6d32HPV\u7684\u611f\u67d3\u7387\u57288.3%\u5de6\u53f3\uff0c\u7565\u4f4e\u4e8e10%\u7684\u4e16\u754c\u5e73\u5747\u6c34\u5e73\u2465\uff0c\u4f46\u8003\u8651\u5230\u4e9a\u6d32\u5e9e\u5927\u7684\u4eba\u53e3\u57fa\u6570\uff0c\u611f\u67d3\u4eba\u6570\u5c06\u4e0d\u53ef\u4f30\u91cf\u3002\u4f17\u591a\u7684HPV\u611f\u67d3\u4eba\u6570\u4e5f\u5bfc\u81f4\u5927\u91cf\u7684\u5bab\u9888\u764c\u60a3\u8005\u3002\u4e2d\u56fd\u5927\u9646\u57282005\u5e74\u5f00\u5c55\u4e8610\u4e07\u5973\u6027\u514d\u8d39\u5bab\u9888\u75be\u75c5\u7b5b\u67e5\u516c\u76ca\u6d3b\u52a8\uff0c\u5728\u7ec6\u80de\u75c5\u7406\u5b66\u5c42\u9762\u88ab\u8bca\u65ad\u4e3a\u5bab\u9888\u764c\u9633\u6027\u7684\u6bd4\u7387\u9ad8\u8fbe158\/10\u4e07\u2466\u3002\u82e5\u628a\u8be5\u6bd4\u7387\u4e58\u4e0a\u5973\u6027\u4eba\u53e3\uff0c\u65e0\u7591\u5c06\u662f\u4e00\u4e2a\u4ee4\u4eba\u548b\u820c\u7684\u6570\u5b57\u2466\u3002\u6839\u636e\u4e2d\u56fd\u75be\u75c5\u9884\u9632\u63a7\u5236\u4e2d\u5fc32005\u5e74\u5f15\u7528\u7684\u62a5\u9053\uff0c\u5bab\u9888\u764c\u53d1\u75c5\u7387\u5df2\u4f4d\u5c45\u4e2d\u56fd\u5973\u6027\u764c\u75c7\u4e4b\u9996\u2466\u3002\u5bab\u9888\u764c\u75ab\u82d7\u7684\u5f15\u8fdb\uff0c\u6709\u671b\u5168\u9762\u6539\u53d8\u8fd9\u4e00\u8ba9\u4eba\u63ea\u5fc3\u7684\u73b0\u72b6\u3002<\/p>\n

\u75ab\u82d7\u5f15\u8fdb\u4e2d\u56fd\u5386\u7ecf\u4e86\u5341\u5e74\u7684\u8def\u7a0b\uff0c\u4f3c\u4e4e\u8fc7\u4e8e\u6f2b\u957f\u4e86\u4e9b\uff0c\u5176\u4e2d\u7684\u66f2\u6298\u81ea\u7136\u662f\u6211\u4eec\u5916\u4eba\u65e0\u4ece\u4e86\u89e3\u7684\u3002\u4f46\u6700\u8fd1\u5173\u4e8e\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u836f\u7269Keytruda\u7684\u6d88\u606f\u4ee4\u4eba\u9f13\u821e\u3002\u8be5\u6297\u764c\u836f\u662fFDA\u4e8e2014\u5e749\u6708\u7ecf\u5feb\u901f\u5ba1\u6279\u901a\u9053(Fast Track)\u6279\u51c6\u4e0a\u5e02\u7684\u2467\uff0c\u57282018\u5e747\u6708\u5c31\u83b7\u5f97\u4e86\u4e2d\u56fd\u5927\u9646\u7684\u8bb8\u53ef\u8bc1\uff0c\u8ddd\u6700\u521dFDA\u7684\u6279\u51c6\u65e5\u8fd8\u4e0d\u5230\u56db\u5e74\u7684\u65f6\u95f4\u3002\u4eceHPV\u75ab\u82d7\u7684\u5341\u5e74\u5230Keytruda\u7684\u4e09\u5e74\u591a\uff0c\u4e2d\u56fd\u5f15\u8fdb\u4e16\u754c\u5148\u8fdb\u9632\u764c\u548c\u6297\u764c\u836f\u7684\u6e20\u9053\u6b63\u5728\u65e5\u6e10\u7545\u901a\uff0c\u8fd9\u662f\u4e2d\u56fd\u75c5\u60a3\u8005\u7684\u798f\u97f3\u3002<\/p>\n

\u5468\u5065\u535a\u58eb\u7684\u4e00\u751f\u662f\u77ed\u6682\u7684\uff0c\u4f46\u4e5f\u662f\u8f89\u714c\u7684\uff0c\u800c\u4ed6\u751f\u524d\u5374\u4e00\u76f4\u8bf4\u81ea\u5df1\u5f88\u5e78\u8fd0\u3002\u56e0\u4e3a\u5728\u4ed6\u5e74\u8f7b\u3001\u6c42\u77e5\u6b32\u6700\u65fa\u76db\u7684\u65f6\u5019\uff0c\u80fd\u6709\u673a\u4f1a\u5230\u5251\u6865\u4ece\u4e8b\u6700\u524d\u6cbf\u7684\u79d1\u5b66\u7814\u7a76\uff0c\u800c\u4e00\u5927\u6279\u540c\u6837\u6709\u624d\u534e\u7684\u5e74\u8f7b\u4eba\u5374\u6ca1\u6709\u8fd9\u6837\u7684\u673a\u4f1a\u3002\u7531\u662f\uff0c\u5468\u5065\u81ea\u51fa\u56fd\u4ee5\u6765\u90fd\u5728\u5c3d\u6700\u5927\u7684\u52aa\u529b\u5e2e\u52a9\u4e2d\u56fd\u7684\u9752\u5e74\u5b66\u5b50\u5230\u5148\u8fdb\u56fd\u5bb6\u5b66\u4e60\uff0c\u8fdb\u4fee\uff0c\u770b\u4e16\u754c\uff0c\u4ee5\u4fc3\u8fdb\u4e2d\u56fd\u4e0e\u5148\u8fdb\u56fd\u5bb6\u7684\u79d1\u7814\u4ea4\u6d41\u4e0e\u5408\u4f5c\u4e3a\u5df1\u4efb\uff0c\u5e76\u5c06\u4e4b\u89c6\u4e3a\u56de\u62a5\u4e2d\u56fd\uff0c\u56de\u62a5\u793e\u4f1a\u7684\u4e00\u79cd\u65b9\u5f0f\uff0c\u76f4\u81f3\u53bb\u4e16\u3002\u4e00\u4e2a\u5bf9\u793e\u4f1a\u4f5c\u51fa\u5982\u6b64\u5de8\u5927\u8d21\u732e\u7684\u4eba\uff0c\u5fc3\u91cc\u65f6\u523b\u60f3\u7740\u7684\u5374\u662f\u611f\u6069\u793e\u4f1a\uff0c\u56de\u9988\u793e\u4f1a\uff0c\u8fd9\u662f\u4f55\u7b49\u7684\u60c5\u6000\u3002<\/p>\n

\u201c\u77e5\u592b\u83ab\u5982\u59bb\u201d\uff0c\u6700\u61c2\u5f97\u5468\u5065\u5185\u5fc3\u7684\u81ea\u7136\u662f\u4ed6\u7684\u59bb\u5b50\u5b59\u5c0f\u4f9d\u5973\u58eb\u3002\u5728\u5468\u5065\u53bb\u4e16\u540e\uff0c\u5c0f\u4f9d\u4e0e\u6606\u58eb\u5170\u5927\u5b66\u5408\u4f5c\u8bbe\u7acb\u57fa\u91d1\uff0c\u8d44\u52a9\u4e2d\u56fd\u7684\u8398\u8398\u5b66\u5b50\u5230\u6606\u5927\u5b66\u4e60\uff0c\u4ee5\u5ef6\u7eed\u5468\u5065\u751f\u524d\u7684\u5fc3\u613f\uff0c\u4e00\u76f4\u575a\u6301\u5230\u4eca\u5929\u3002\u6211\u4eec\u4e3a\u5bab\u9888\u764c\u75ab\u82d7\u6240\u53d1\u6325\u7684\u5de8\u5927\u793e\u4f1a\u6548\u76ca\u51fb\u638c\u76f8\u5e86\u7684\u540c\u65f6\uff0c\u4e5f\u88ab\u5468\u5065\u53ca\u5176\u5bb6\u4eba\u8fd9\u79cd\u5d07\u9ad8\u7684\u60c5\u6000\u6df1\u6df1\u5730\u611f\u52a8\u3002<\/p>\n

\u5e0c\u671b\u672c\u4e66\u80fd\u8ba9\u66f4\u591a\u7684\u4eba\u8ba4\u8bc6\u5468\u5065\uff0c\u4e86\u89e3\u4ed6\u7684\u5353\u8d8a\u8d21\u732e\uff0c\u8bfb\u61c2\u4ed6\u7684\u7cbe\u795e\u9057\u4ea7\u3002<\/p>\n

\u7f16\u8005<\/p>\n

2018\u5e748\u670828\u65e5<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/p>\n

\u2460\uff0eExpression of vaccinia recombinant HPV 16 L1 and L2 ORF proteins in epithelial cells is sufficient for assembly of HPV virion-like particles by Zhou J, Sun XY, Stenzel DJ, Frazer IH from Virology. 1991, 185 (1):251-7.<\/p>\n

\u2461. Human Papillomavirus (HPV) Vaccines published by National Cancer Institute at\u00a0https:\/\/www.cancer.gov\/about-cancer\/causes-prevention\/risk\/infectious-agents\/hpv-vaccine-fact-sheet<\/a><\/p>\n

\u2462. On the case, a Q & A with Harald zur Hausen from Nature 2012, Vol 488, S16.<\/p>\n

\u2463. Efficacy of a bivalent HPV 16\/18 vaccine against anal HPV 16\/18 infection among young women: a nested analysis within the Costa Rica Vaccine Trial by Kreimer AR, et al. from Lancet Oncol. 2011 12(9):862-70.<\/p>\n

\u2464. HPV-Associated Head and Neck Cancer by Everett E.et al. from Journal of the National Cancer Institute, 2015, Volume 107, Issue 12, 1.<\/p>\n

\u2465\uff0eHPV: the global burden by James Mitchell Crow from Nature 2012, vol 488, S2-3.<\/p>\n

\u2466. Chinese Center for Disease Control & Prevention at\u00a0http:\/\/www.chinacdc.cn\/n272442\/n272530\/n272817\/n272877\/10663.html<\/a><\/p>\n

\u2467. Pembrolizumab from\u00a0https:\/\/en.wikipedia.org\/wiki\/Pembrolizumab#History<\/a><\/p>\n

<\/p>\n

\u8fd9\u662f2018\u5e7410\u6708\u51fa\u7248\u7684\u8be5\u4e66\u7b2c\u4e8c\u7248\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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